Near-zero-energy end states in topologically trivial spin-orbit coupled superconducting nanowires with a smooth confinement

A one-dimensional spin-orbit coupled nanowire with proximity-induced pairing from a nearby s-wave superconductor may be in a topological nontrivial state, in which it has a zero energy Majorana bound state at each end. We find that the topological trivial phase may have fermionic end states with an exponentially small energy, if the confinement potential at the wire's ends is smooth. The possible existence of such near-zero energy levels implies that the mere observation of a zero-bias peak in the tunneling conductance is not an exclusive signature of a topological superconducting phase even in the ideal clean single channel limit.Comment: 4 pages, 4 figure

Enhanced zero-bias Majorana peak in disordered multi-subband quantum wires

A recent experiment [Mourik et al., Science 336, 1003 (2012)] on InSb quantum wires provides possible evidence for the realization of a topological superconducting phase and the formation of Majorana bound states. Motivated by this experiment, we consider the signature of Majorana bound states in the differential tunneling conductance of multi-subband wires. We show that the weight of the Majorana-induced zero-bias peak is strongly enhanced by mixing of subbands, when disorder is added to the end of the quantum wire. We also consider how the topological phase transition is reflected in the gap structure of the current-voltage characteristic.Comment: 4+ pages, 5 figures, minor changes in the text and Fig. 5, references added; published versio

Arm cavity resonant sideband control for laser interferometric gravitational wave detectors

We present a new optical control scheme for a laser interferometric gravitational wave detector that has a high degree of tolerance to interferometer spatial distortions and noise on the input light. The scheme involves resonating the rf sidebands in an interferometer arm cavity

Model of Thermal Wavefront Distortion in Interferometric Gravitational-Wave Detectors I: Thermal Focusing

We develop a steady-state analytical and numerical model of the optical response of power-recycled Fabry-Perot Michelson laser gravitational-wave detectors to thermal focusing in optical substrates. We assume that the thermal distortions are small enough that we can represent the unperturbed intracavity field anywhere in the detector as a linear combination of basis functions related to the eigenmodes of one of the Fabry-Perot arm cavities, and we take great care to preserve numerically the nearly ideal longitudinal phase resonance conditions that would otherwise be provided by an external servo-locking control system. We have included the effects of nonlinear thermal focusing due to power absorption in both the substrates and coatings of the mirrors and beamsplitter, the effects of a finite mismatch between the curvatures of the laser wavefront and the mirror surface, and the diffraction by the mirror aperture at each instance of reflection and transmission. We demonstrate a detailed numerical example of this model using the MATLAB program Melody for the initial LIGO detector in the Hermite-Gauss basis, and compare the resulting computations of intracavity fields in two special cases with those of a fast Fourier transform field propagation model. Additional systematic perturbations (e.g., mirror tilt, thermoelastic surface deformations, and other optical imperfections) can be included easily by incorporating the appropriate operators into the transfer matrices describing reflection and transmission for the mirrors and beamsplitter.Comment: 24 pages, 22 figures. Submitted to JOSA

Endstates in multichannel spinless p-wave superconducting wires

Multimode spinless p-wave superconducting wires with a width W much smaller than the superconducting coherence length \xi are known to have multiple low-energy subgap states localized near the wire's ends. Here we compare the typical energies of such endstates for various terminations of the wire: A superconducting wire coupled to a normal-metal stub, a weakly disordered superconductor wire and a wire with smooth confinement. Depending on the termination, we find that the energies of the subgap states can be higher or lower than for the case of a rectangular wire with hard-wall boundaries.Comment: 10 pages, 7 figure

Interacting non-Abelian anyons as Majorana fermions in the honeycomb lattice model

We study the collective states of interacting non-Abelian anyons that emerge in Kitaev's honeycomb lattice model. Vortex-vortex interactions are shown to lead to the lifting of the topological degeneracy and the energy is discovered to exhibit oscillations that are consistent with Majorana fermions being localized at vortex cores. We show how to construct states corresponding to the fusion channel degrees of freedom and obtain the energy gaps characterizing the stability of the topological low energy spectrum. To study the collective behavior of many vortices, we introduce an effective lattice model of Majorana fermions. We find necessary conditions for it to approximate the spectrum of the honeycomb lattice model and show that bi-partite interactions are responsible for the degeneracy lifting also in many vortex systems.Comment: 22 pages, 12 figures, published versio

Enhanced Zero-Bias Majorana Peak in the Differential Tunneling Conductance of Disordered Multisubband Quantum-Wire/Superconductor Junctions

A recent experiment Mourik et al. [Science 336, 1003 (2012)] on InSb quantum wires provides possible evidence for the realization of a topological superconducting phase and the formation of Majorana bound states. Motivated by this experiment, we consider the signature of Majorana bound states in the differential tunneling conductance of multisubband wires. We show that the weight of the Majorana-induced zero-bias peak is strongly enhanced by mixing of subbands, when disorder is added to the end of the quantum wire. We also consider how the topological phase transition is reflected in the gap structure of the current-voltage characteristic

Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease.

ObjectiveTo understand the safety, putaminal coverage, and enzyme expression of adeno-associated viral vector serotype-2 encoding the complementary DNA for the enzyme, aromatic L-amino acid decarboxylase (VY-AADC01), delivered using novel intraoperative monitoring to optimize delivery.MethodsFifteen subjects (three cohorts of 5) with moderately advanced Parkinson's disease and medically refractory motor fluctuations received VY-AADC01 bilaterally coadministered with gadoteridol to the putamen using intraoperative magnetic resonance imaging (MRI) guidance to visualize the anatomic spread of the infusate and calculate coverage. Cohort 1 received 8.3 × 1011 vg/ml and ≤450 μl per putamen (total dose, ≤7.5 × 1011 vg); cohort 2 received the same concentration (8.3 × 1011 vg/ml) and ≤900 μl per putamen (total dose, ≤1.5 × 1012 vg); and cohort 3 received 2.6 × 1012 vg/ml and ≤900 μl per putamen (total dose, ≤4.7 × 1012 vg). (18)F-fluoro-L-dihydroxyphenylalanine positron emission tomography (PET) at baseline and 6 months postprocedure assessed enzyme activity; standard assessments measured clinical outcomes.ResultsMRI-guided administration of ascending VY-AADC01 doses resulted in putaminal coverage of 21% (cohort 1), 34% (cohort 2), and 42% (cohort 3). Cohorts 1, 2, and 3 showed corresponding increases in enzyme activity assessed by PET of 13%, 56%, and 79%, and reductions in antiparkinsonian medication of -15%, -33%, and -42%, respectively, at 6 months. At 12 months, there were dose-related improvements in clinical outcomes, including increases in patient-reported ON-time without troublesome dyskinesia (1.6, 3.3, and 1.5 hours, respectively) and quality of life.InterpretationNovel intraoperative monitoring of administration facilitated targeted delivery of VY-AADC01 in this phase 1 study, which was well tolerated. Increases in enzyme expression and clinical improvements were dose dependent. ClinicalTrials.gov Identifier: NCT01973543 Ann Neurol 2019;85:704-714

Multi-wavelength Observations of Dusty Star Formation at Low and High Redshift

This paper examines what can be learned about high-redshift star formation from the small fraction of high-redshift galaxies' luminosities that is emitted at accessible wavelengths. We review and quantify empirical correlations between bolometric luminosities produced by star formation and the UV, mid-IR, sub-mm, and radio luminosities of galaxies in the local universe. These correlations suggest that observations of high-redshift galaxies at any of these wavelengths should constrain their star-formation rates to within 0.2--0.3 dex. We assemble the limited evidence that high-redshift galaxies obey these locally calibrated correlations. The characteristic luminosities and dust obscurations of galaxies at z ~ 0, z ~ 1, and z ~ 3 are reviewed. After discussing the relationship between the high-redshift populations selected in surveys at different wavelengths, we calculate the contribution to the 850um background from each. The available data show that a correlation between star-formation rate and dust obscuration L_dust/L_UV exists at low and high redshift. This correlation plays a central role in the major conclusion of this paper: most star formation at high redshift occurred in galaxies with 1 < L_dust/L_UV < 100 similar to those that host the majority of star formation in the local universe and to those that are detected in UV-selected surveys. (abridged)Comment: Scheduled for publication in ApJ v544 Dec 2000. Significant changes to section 4. Characteristic UV and dust luminosities of star-forming galaxies at redshifts z~0, z~1, and z~3 presented. Existence of extremely obscured galaxies more clearly acknowledged. Original conclusions reinforced by the observed correlation between bolometric luminosity and dust obscuration at 0<z<